IsoRank PPI Network Alignment Based Ortholog Database

About IsoBase

Welcome! Thanks for your interest in IsoBase. The IsoBase (IsoRank PPI Network Alignment Based Ortholog Database) is a functional ortholog database developed by global network alignment tools IsoRank & IsoRankN on multiple alignments of the five available eukaryotic PPI networks. Functional orthologs that better conserve protein function across species identify genes in different species derived from the same ancestral region. We demonstrate that incorporating PPI network data in ortholog prediction results in improvements over existing sequence-only approaches and over predictions from local alignments. The IsoBase ortholog database is a collection of functional orthologs across multiple species including Saccharomyces cerevisiae (Yeast), Drosophila melanogaster (Fly), Caenorhabditis elegans (Worm), Mus musculus (Mouse), and Homo sapiens (Human) PPI networks. The IsoBase is available for both online access and download. Users are able to have options to obtain all the functional orthologs across multiple species. Users can also search for orthologs based on constituent gene ID/name.


Eukaryotic species: 5
Protein sequences: 87737
Ortholog number: 12848
Constituent protein number: 48978

Last updated on July 1, 2010


The project has been supported by MIT, NTHU, ......

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